Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1
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چکیده
منابع مشابه
Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1
Mechanistic investigations have shown that, upon agonist activation, hydroxy-carboxylic acid receptor-1(HCA1) couples to a Gi protein and inhibits adenylate cyclase activity, leading to inhibition of liberation of free fatty acid. However, the underlying molecular mechanisms for HCA1 signaling remain largely unknown. Using CHO-K1 cells stably expressing HCA1, and L6 cells, which endogenously ex...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0093041